Ontology highlight
ABSTRACT:
SUBMITTER: Kim YS
PROVIDER: S-EPMC7140404 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Cells 20200306 3
Peroxisome proliferator-activated receptor α (PPARα) shows promising potential to enhance host defenses against <i>Mycobacterium tuberculosis</i> infection. Herein we evaluated the protective effect of PPARα against nontuberculous mycobacterial (NTM) infections. Using a rapidly growing NTM species, <i>Mycobacterium abscessus</i> (Mabc), we found that the intracellular bacterial load and histopathological damage were increased in PPARα-null mice in vivo. In addition, PPARα deficiency led to exces ...[more]