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Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis.

ABSTRACT: A novel 5-membered iminocyclitol derivative was found to be a potent and selective inhibitor of the glycoprotein-processing alpha-glucosidase with a Ki value of 53 nM. This compound was further derivatized to antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN-2), human SARS coronavirus, and human beta-hexosaminidase (Ki = 2.6 nM), a new target for the development of osteoarthritis therapeutics.

SUBMITTER: Liang PH

PROVIDER: S-EPMC7161998 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature

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Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis.

Liang Pi-Hui PH Cheng Wei-Chieh WC Lee Yi-Ling YL Yu Han-Pang HP Wu Ying-Ta YT Lin Yi-Ling YL Wong Chi-Huey CH

Chembiochem : a European journal of chemical biology 20060101 1

A novel 5-membered iminocyclitol derivative was found to be a potent and selective inhibitor of the glycoprotein-processing alpha-glucosidase with a Ki value of 53 nM. This compound was further derivatized to antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN-2), human SARS coronavirus, and human beta-hexosaminidase (Ki = 2.6 nM), a new target for the development of osteoarthritis therapeutics. ...[more]

PMID: 16397876

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