Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff bases.

ABSTRACT: Sulphonamides are biologically important compounds with low toxicity, many bioactivities and cost-effectiveness. Eight sulphonamide derivatives were synthesised and characterised by FT-IR, ¹³C NMR, ¹H NMR, LC-MS and elemental analysis. Their inhibitory effect on AChE, and carbonic anhydrase I and II enzyme activities was investigated. Their antioxidant activity was determined using different bioanalytical assays such as radical scavenging tests with ABTS^•+, and DPPH^•+ as well as metal-reducing abilities with CUPRAC, and FRAP assays. All compounds showed satisfactory enzyme inhibitory potency in nanomolar concentrations against AChE and CA isoforms with K_I values ranging from 10.14 ± 0.03 to 100.58 ± 1.90 nM. Amine group containi

SUBMITTER: Durgun M 

PROVIDER: S-EPMC7170330 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature