Dataset Information
Clinical impact of rapid molecular detection of respiratory pathogens in patients with acute respiratory infection.
Ontology highlight
ABSTRACT: Background
Acute respiratory infections (ARI) are a leading cause of morbidity and mortality worldwide. There is a need to demonstrate the clinical impact of using the new, rapid and sensitive molecular assays in prospectively designed studies.Objectives
To study the impact on medical management of a rapid molecular assay in patients with respiratory infections.Study design
A prospective, randomized, non-blinded study was performed in patients presenting to the Emergency Department during two respiratory seasons (2016-2017). Diagnosis was performed by FilmArray Respiratory Panel (FilmArray-RP) or by immunofluorescence assay (IFA).Results
A total of 432 patients (156 children and 276 adults) were analyzed. Diagnosis with FilmArray-RP was associated with significant changes in medical management including withholding antibiotic prescriptions (OR:15.52, 95%CI:1.99-120.83 in adults and OR:12.23, 95%CI:1.56-96.09 in children), and reduction in complementary studies in children (OR:9.64, 95%CI:2.13-43.63) compared to IFA. Decrease in oseltamivir prescriptions was significantly higher in adults in the FilmArray-RP group (p = 0.042; OR:1.19, 95%CI:0.51-2.79) compared to adults managed with IFA. Diagnostic yield was significantly higher by FilmArray-RP (81%) than by IFA (31%)(p < 0.001). The median time from sample collection to reporting was 1 h 52 min by FilmArray-RP and 26 h by IFA (p < 0.001).Conclusions
The high respiratory viruses' detection rate and availability of results within two hours when using FilmArray-RP were associated with decreases in antibiotic prescriptions and complementary studies and more accurate use of oseltamivir.
SUBMITTER: Echavarria M
PROVIDER: S-EPMC7172208 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Clinical impact of rapid molecular detection of respiratory pathogens in patients with acute respiratory infection.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20180914
<h4>Background</h4>Acute respiratory infections (ARI) are a leading cause of morbidity and mortality worldwide. There is a need to demonstrate the clinical impact of using the new, rapid and sensitive molecular assays in prospectively designed studies.<h4>Objectives</h4>To study the impact on medical management of a rapid molecular assay in patients with respiratory infections.<h4>Study design</h4>A prospective, randomized, non-blinded study was performed in patients presenting to the Emergency ...[more]
