Ontology highlight
ABSTRACT:
SUBMITTER: Puszko AK
PROVIDER: S-EPMC7175122 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Biomolecules 20200313 3
The structure-activity relationship of branched H-Lys(<i>h</i>Arg)-Dab-Dhp-Arg-OH sequence analogues, modified with Cys-Asp or Cys at N-terminal amino acids (Lys, <i>h</i>Arg), in VEGF-A<sub>165</sub>/Neuropilin-1 complex inhibition is presented. The addition of Cys residue led to a 100-fold decrease in the IC<sub>50</sub> value, compared to the parent peptide. The change occurred regardless of coupling Cys to the free N-terminal amino group present in the main or the side chain. A few analogues ...[more]