Expression of Tight Junction Proteins According to Functional Dyspepsia Subtype and Sex.

ABSTRACT:

Background/aims

To determine whether the expression of tight junction proteins (TJPs) differs depending on the subtype of functional dyspepsia (FD) and sex.

Methods

Control (n = 95) and FD (n = 165) groups based on Rome III criteria were prospectively enrolled. Gastric mucosal mRNA expression levels of various TJPs (claudins [CLDN] 1, 2, and 4; zonula occludens-1; occludin [OCLN]) were assessed by reverse transcription polymerase chain reaction. Western blot was performed to determine the levels of various TJPs. Helicobacter pylori infection status was evaluated by histology, rapid urease test, and culture. Questionnaires were analyzed.

Results

In all groups irrespective of H. pylori , FD group showed significantly higher CLDN2 mRNA levels than control g

SUBMITTER: Lee JY 

PROVIDER: S-EPMC7176499 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature