Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons.

ABSTRACT: The dorsal raphe nucleus is the predominant source of central serotonin, where neuronal activity regulates complex emotional behaviors. Action potential firing of serotonin dorsal raphe neurons is driven via α1-adrenergic receptors (α1-A_R) activation. Despite this crucial role, the ion channels responsible for α1-A_R-mediated depolarization are unknown. Here, we show in mouse brain slices that α1-A_R-mediated excitatory synaptic transmission is mediated by the ionotropic glutamate receptor homolog cation channel, delta glutamate receptor 1 (GluD1). GluD1_R-channels are constitutively active under basal conditions carrying tonic inward current and synaptic activation of α1-A_Rs augments tonic GluD1_R-channel current. Further, loss

SUBMITTER: Gantz SC 

PROVIDER: S-EPMC7180053 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature