Ontology highlight
ABSTRACT:
SUBMITTER: Whisnant AW
PROVIDER: S-EPMC7184758 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Nature communications 20200427 1
The predicted 80 open reading frames (ORFs) of herpes simplex virus 1 (HSV-1) have been intensively studied for decades. Here, we unravel the complete viral transcriptome and translatome during lytic infection with base-pair resolution by computational integration of multi-omics data. We identify a total of 201 transcripts and 284 ORFs including all known and 46 novel large ORFs. This includes a so far unknown ORF in the locus deleted in the FDA-approved oncolytic virus Imlygic. Multiple transcr ...[more]