The structure of the influenza A virus genome.

ABSTRACT: Influenza A viruses (IAVs) constitute a major threat to human health. The IAV genome consists of eight single-stranded viral RNA segments contained in separate viral ribonucleoprotein (vRNP) complexes that are packaged together into a single virus particle. The structure of viral RNA is believed to play a role in assembling the different vRNPs into budding virions^1-8 and in directing reassortment between IAVs⁹. Reassortment between established human IAVs and IAVs harboured in the animal reservoir can lead to the emergence of pandemic influenza strains to which there is little pre-existing immunity in the human population^10,11. While previous studies have revealed the overall organization of the proteins within vRNPs, characterization of viral RNA structure

SUBMITTER: Dadonaite B 

PROVIDER: S-EPMC7191640 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature