Pharmacological prevention of surgery-accelerated metastasis in an animal model of osteosarcoma.

ABSTRACT:

Background

Osteosarcoma is a highly metastatic primary bone tumor that predominantly affects adolescents and young adults. A mainstay of treatment in osteosarcoma is removal of the primary tumor. However, surgical excision itself has been implicated in promoting tumor growth and metastasis, an effect known as surgery-accelerated metastasis. The underlying mechanisms contributing to surgery-accelerated metastasis remain poorly understood, but pro-tumorigenic alterations in macrophage function have been implicated.

Methods

The K7M2-BALB/c syngeneic murine model of osteosarcoma was used to study the effect of surgery on metastasis, macrophage phenotype, and overall survival. Pharmacological prevention of surgery-accelerated metastasis was examined utilizing gefitinib, a recepto

SUBMITTER: Kallis MP 

PROVIDER: S-EPMC7193344 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature