The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development.

ABSTRACT: The formation of the craniofacial skeleton is a highly dynamic process that requires proper orchestration of various cellular processes in cranial neural crest cell (cNCC) development, including cell migration, proliferation, differentiation, polarity and cell death. Alterations that occur during cNCC development result in congenital birth defects and craniofacial abnormalities such as cleft lip with or without cleft palate. While the gene regulatory networks facilitating neural crest development have been extensively studied, the epigenetic mechanisms by which these pathways are activated or repressed in a temporal and spatially regulated manner remain largely unknown. Chromatin modifiers can precisely modify gene expression through a variety of mechanisms including histone modifications

SUBMITTER: Shull LC 

PROVIDER: S-EPMC7198358 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature