Ontology highlight
ABSTRACT:
SUBMITTER: Penfield L
PROVIDER: S-EPMC7199858 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
The Journal of cell biology 20200501 5
The nuclear permeability barrier depends on closure of nuclear envelope (NE) holes. Here, we investigate closure of the NE opening surrounding the meiotic spindle in C. elegans oocytes. ESCRT-III components accumulate at the opening but are not required for nuclear closure on their own. 3D analysis revealed cytoplasmic membranes directly adjacent to NE holes containing meiotic spindle microtubules. We demonstrate that the NE protein phosphatase, CNEP-1/CTDNEP1, controls de novo glycerolipid synt ...[more]