Ontology highlight
ABSTRACT:
SUBMITTER: Jeong HJ
PROVIDER: S-EPMC7206020 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Cell death and differentiation 20190626 2
MyoD functions as a master regulator to induce muscle-specific gene expression and myogenic differentiation. Here, we demonstrate a positive role of Protein arginine methyltransferase 7 (Prmt7) in MyoD-mediated myoblast differentiation through p38MAPK activation. Prmt7 depletion in primary or C2C12 myoblasts impairs cell cycle withdrawal and myogenic differentiation. Furthermore, Prmt7 depletion decreases the MyoD-reporter activities and the MyoD-mediated myogenic conversion of fibroblasts. Toge ...[more]