Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN).

ABSTRACT:

Introduction

Although some members of families with autosomal dominant Alzheimer's disease mutations learn their mutation status, most do not. How knowledge of mutation status affects clinical disease progression is unknown. This study quantifies the influence of mutation awareness on clinical symptoms, cognition, and biomarkers.

Methods

Mutation carriers and non-carriers from the Dominantly Inherited Alzheimer Network (DIAN) were stratified based on knowledge of mutation status. Rates of change on standard clinical, cognitive, and neuroimaging outcomes were examined.

Results

Mutation knowledge had no associations with cognitive decline, clinical progression, amyloid deposition, hippocampal volume, or depression in either carriers or non-carriers. Carriers who learned

SUBMITTER: Aschenbrenner AJ 

PROVIDER: S-EPMC7206736 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature