Dynamics of peripheral immune cells and their HLA-G and receptor expressions in a patient suffering from critical COVID-19 pneumonia to convalescence.

ABSTRACT:

Objectives

Host immune responses are indispensable to combat the disease. We report the dynamics of peripheral immune cells, cytokines, and human leucocyte antigen-G (HLA-G) and its receptor expressions in a patient suffering from critical COVID-19 pneumonia to convalescence.

Methods

Clinical data of the patient were collected from medical records. The expressions of HLA-G and receptors ILT2, ILT4 and KIR2DL4 in peripheral immune cells were measured with flow cytometry.

Results

From critical COVID-19 to the convalescent stage, early lymphopenia was improved (median: 0.6 × 10⁹ L^-1 vs. 0.9 × 10⁹ L^-1, P = 0.009), and an obvious fluctuation in WBC and neutrophil counts was observed. Initially, low levels of CD4⁺

SUBMITTER: Zhang S 

PROVIDER: S-EPMC7211507 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature