Ontology highlight
ABSTRACT:
SUBMITTER: Chen YC
PROVIDER: S-EPMC7212047 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Nature genetics 20150525 7
Pain perception has evolved as a warning mechanism to alert organisms to tissue damage and dangerous environments. In humans, however, undesirable, excessive or chronic pain is a common and major societal burden for which available medical treatments are currently suboptimal. New therapeutic options have recently been derived from studies of individuals with congenital insensitivity to pain (CIP). Here we identified 10 different homozygous mutations in PRDM12 (encoding PRDI-BF1 and RIZ homology ...[more]