Tumor-associated macrophage infiltration in meningioma.

ABSTRACT:

Background

Meningioma, a most common brain tumor, has a high rate of recurrence. Tumor-associated macrophages (TAMs) are the most abundant immune cell type in meningioma. TAMs display functional phenotypic diversity and may establish either an inflammatory and anti-tumoral or an immunosuppressive and pro-tumoral microenvironment. TAM subtypes present in meningioma and potential contribution to growth and recurrence is unknown.

Methods

Immunofluorescence staining was used to quantify M1 and M2 TAM populations in tissues obtained from 30 meningioma patients. Associations between M1 and M2 cells, M1:M2 cell ratio to tumor characteristics, WHO grade, recurrence, size, location, peri-tumoral edema, and patient demographics such as age and sex were examined.

Results

TAM cel

SUBMITTER: Proctor DT 

PROVIDER: S-EPMC7212927 | biostudies-literature | 2019 May-Dec

REPOSITORIES: biostudies-literature