Ontology highlight
ABSTRACT:
SUBMITTER: Nakayama M
PROVIDER: S-EPMC7214469 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nature communications 20200511 1
Missense-type mutant p53 plays a tumor-promoting role through gain-of-function (GOF) mechanism. In addition, the loss of wild-type TP53 through loss of heterozygosity (LOH) is widely found in cancer cells. However, malignant progression induced by cooperation of TP53 GOF mutation and LOH remains poorly understood. Here, we show that mouse intestinal tumors carrying Trp53 GOF mutation with LOH (AKTP<sup>M/LOH</sup>) are enriched in metastatic lesions when heterozygous Trp53 mutant cells (AKTP<sup ...[more]