Effects of co-exposure to CS₂ and noise on hearing and balance in rats: continuous versus intermittent CS₂ exposures.

ABSTRACT:

Background

Carbon disulfide (CS₂) exacerbates the effect of noise on hearing, and disrupts the vestibular system. The goal of this study was to determine whether these effects are also observed with intermittent CS₂ exposure.

Methods

Rats were exposed for 4 weeks (5 days/week, 6 h/day) to a band noise at 106 dB SPL either alone or combined with continuous (63 ppm or 250 ppm) or intermittent (15 min/h or 2 × 15 min/h at 250 ppm) CS₂. Hearing function was assessed by measuring distortion product otoacoustic emissions (DPOAEs); balance was monitored based on the vestibulo-ocular reflex (VOR). Functional measurements were performed before, at the end of exposure and 4 weeks later. Histological analyses of the inner ear were also performed followi

SUBMITTER: Chalansonnet M 

PROVIDER: S-EPMC7216478 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature