Association of interleukin 10 rs1800896 polymorphism with susceptibility to breast cancer: a meta-analysis.

ABSTRACT:

Objective

To evaluate the correlation between interleukin 10 (IL-10) -1082A/G polymorphism (rs1800896) and breast cancers by performing a meta-analysis.

Methods

The Embase and Medline databases were searched through 1 September 2018 to identify qualified articles. Odds ratios (OR) and corresponding 95% confidence intervals (CIs) were applied to evaluate associations.

Results

In total, 14 case-control studies, including 5320 cases and 5727 controls, were analyzed. We detected significant associations between the IL10 -1082 G/G genotype and risk of breast cancer (AA + AG vs. GG: OR = 0.88, 95% CI = 0.80-0.97). Subgroup analyses confirmed a significant association in Caucasian populations (OR = 0.89, 95% CI = 0.80-0.99), in population-based case-control studies (O

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC7218478 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature