Designing of Chitosan Derivatives Nanoparticles with Antiangiogenic Effect for Cancer Therapy.

ABSTRACT: Angiogenesis is a physiological process involving the growth of new blood vessels, which provides oxygen and required nutrients for the development of various pathological conditions. In a tumor microenvironment, this process upregulates the growth and proliferation of tumor cells, thus any stage of angiogenesis can be a potential target for cancer therapies. In the present study, chitosan and his derivatives have been used to design novel polymer-based nanoparticles. The therapeutic potential of these newly designed nanoparticles has been evaluated. The antioxidant and MTT assays were performed to know the antioxidant properties and their biocompatibility. The in vivo antiangiogenic properties of the nanoparticles were evaluated by using a chick Chorioallantoic Membrane (CAM) model. The o

SUBMITTER: Dragostin OM 

PROVIDER: S-EPMC7221956 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature