Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients.

ABSTRACT:

Background

Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences.

Methods

Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females).

Results

Among males, tumor (T1Gd) radius was a predictor of overall survival (HR = 1.027, p = 0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR = 1.011, p < 0.001). Female extreme survivors had significantly smaller tumors (T1Gd) (p = 0.010 t-test)

SUBMITTER: Whitmire P 

PROVIDER: S-EPMC7238585 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature