Dataset Information

Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients.

ABSTRACT:

Background

Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences.

Methods

Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females).

Results

Among males, tumor (T1Gd) radius was a predictor of overall survival (HR?=?1.027, p?=?0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR?=?1.011, p?ConclusionDespite similar distributions of the MR imaging parameters between males and females, there was a sex-specific difference in how these parameters related to outcomes.

SUBMITTER: Whitmire P

PROVIDER: S-EPMC7238585 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Publications

Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients.

Whitmire Paula P Rickertsen Cassandra R CR Hawkins-Daarud Andrea A Carrasco Eduardo E Lorence Julia J De Leon Gustavo G Curtin Lee L Bayless Spencer S Clark-Swanson Kamala K Peeri Noah C NC Corpuz Christina C Lewis-de Los Angeles Christine Paula CP Bendok Bernard R BR Gonzalez-Cuyar Luis L Vora Sujay S Mrugala Maciej M MM Hu Leland S LS Wang Lei L Porter Alyx A Kumthekar Priya P Johnston Sandra K SK Egan Kathleen M KM Gatenby Robert R Canoll Peter P Rubin Joshua B JB Swanson Kristin R KR

BMC cancer 20200519 1

<h4>Background</h4>Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences.<h4>Methods</h4>Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females).<h4>Results</h4>A ...[more]

PMID: 32429869

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Dataset Information

Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients.

Background

Methods

Results

Publications

Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients.

Similar Datasets

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