Role of PKCε in the epithelial-mesenchymal transition induced by FGFR2 isoform switch.

ABSTRACT:

Background

The epithelial isoform of the fibroblast growth factor receptor 2 (FGFR2b) controls the entire program of keratinocyte differentiation via the sequential involvement of protein kinase C (PKC) δ and PKCα. In contrast, the FGFR2 isoform switch and the aberrant expression of the mesenchymal FGFR2c isoform leads to impairment of differentiation, epithelial-mesenchymal transition (EMT) and tumorigenic features. Aim of our present study was to contribute in clarifying the complex network of signaling pathways involved in the FGFR2c-mediated oncogenic outcomes focusing on PKCε, which appears to be involved in the induction of EMT and tumorigenesis in several epithelial contexts.

Methods

Biochemical and molecular analysis, as well as in vitro invasion assays, combined wit

SUBMITTER: Ranieri D 

PROVIDER: S-EPMC7238605 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature