Ontology highlight
ABSTRACT:
SUBMITTER: Romeo JR
PROVIDER: S-EPMC7239334 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Romeo Joseph R JR McDermott Luca L Bennett Clay S CS
Organic letters 20200413 9
The first synthesis of the tetrasaccharide fragment of the anthracycline natural product Arugomycin is described. A reagent controlled dehydrative glycosylation method involving cyclopropenium activation was utilized to synthesize the α-linkages with complete anomeric selectivity. The synthesis was completed in 20 total steps, and in 2.5% overall yield with a longest linear sequence of 15 steps. ...[more]