Forcing the ribosome to change its message.
Ontology highlight
ABSTRACT:
SUBMITTER: Leininger SE
PROVIDER: S-EPMC7242706 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Forcing the ribosome to change its message.
Leininger Sarah E SE Deutsch Carol C O'Brien Edward P EP
The Journal of biological chemistry 20200501 20
Mechanical forces can be generated when nascent protein segments are integrated into a membrane. These forces are then transmitted through the nascent protein to the ribosome's catalytic core, but only a few biological consequences of this process have been identified to date. In this issue, Harrington <i>et al.</i> present evidence that these forces form a conserved mechanism to influence the efficiency of ribosomal frameshifting during translation of viral RNA, indicating that mechanical force ...[more]
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