Ontology highlight
ABSTRACT:
SUBMITTER: Alvisi G
PROVIDER: S-EPMC7260038 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20200601 6
The molecular mechanisms responsible for the high immunosuppressive capacity of CD4+ Tregs in tumors are not well known. High-dimensional single-cell profiling of T cells from chemotherapy-naive individuals with non-small-cell lung cancer identified the transcription factor IRF4 as specifically expressed by a subset of intratumoral CD4+ effector Tregs with superior suppressive activity. In contrast to the IRF4- counterparts, IRF4+ Tregs expressed a vast array of suppressive molecules, and their ...[more]