Occupational livestock or animal dust exposure and offspring cancer risk in Denmark, 1968-2016.

ABSTRACT:

Objective

To examine associations with occupational livestock or other animal dust exposure and offspring cancer risk.

Methods

In this population-based case-control study of Danish children aged < 17 years old, 5078 childhood cancer cases diagnosed 1968-2016 were matched to cancer-free controls by birth year and sex (n = 123,228). Occupational livestock or animal dust exposure was identified using a job-exposure matrix. We employed multivariable conditional logistic regression models to estimate associations with offspring cancer for births 1968-2016 and 1989-2016, with the latter timeframe reflecting a period of presumed higher exposure due to changes in Danish farming practices. Sensitivity analyses considered place of birth (urban areas vs. rural areas and small towns).

SUBMITTER: Hall C 

PROVIDER: S-EPMC7261625 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature