The preliminary association study of osteopontin 707 C/T polymorphism with systemic lupus erythematosus in a Polish population.

ABSTRACT:

Introduction

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease caused by genetic, environmental, and still unknown factors which lead to deregulation of the immune system. Osteopontin (OPN) is a multifunctional glycoprotein, expressed in various cell types, and found to play key roles in immunity. OPN and variants of the OPN gene are involved in inflammatory conditions, however, their role in SLE are controversial.

Aim

To investigate the frequency of single nucleotide polymorphism (SNP) rs1126616 (707 C/T) variants in the OPN gene and its associations with SLE manifestations in Polish patients.

Material and methods

The study population consisted of 83 SLE patients and 100 gender-, age- and ethnically matched healthy controls. DNA was extracted from wh

SUBMITTER: Kaleta B 

PROVIDER: S-EPMC7262818 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature