Factors associated with sharing e-mail information and mental health survey participation in large population cohorts.

ABSTRACT:

Background

People who opt to participate in scientific studies tend to be healthier, wealthier and more educated than the broader population. Although selection bias does not always pose a problem for analysing the relationships between exposures and diseases or other outcomes, it can lead to biased effect size estimates. Biased estimates may weaken the utility of genetic findings because the goal is often to make inferences in a new sample (such as in polygenic risk score analysis).

Methods

We used data from UK Biobank, Generation Scotland and Partners Biobank and conducted phenotypic and genome-wide association analyses on two phenotypes that reflected mental health data availability: (i) whether participants were contactable by e-mail for follow-up; and (ii) whether parti

SUBMITTER: Adams MJ 

PROVIDER: S-EPMC7266553 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature