Histopathology and genetic susceptibility in COVID-19 pneumonia.

ABSTRACT:

Background

The clinical features of COVID-19 pneumonia range from a mild illness to patients with a very severe illness with acute hypoxemic respiratory failure requiring ventilation and Intensive Care Unit admission.

Aims

To provide a brief overview of the existing evidence for such differences in host response and outcome, and generate hypotheses for divergent patterns and avenues for future research, by highlighting similarities and differences in histopathological appearance between COVID-19 and influenza as well as previous coronavirus outbreaks, and by discussing predisposition through genetics and underlying disease.

Materials and method

We assessed the available early literature for histopathological patterns of COVID-19 pneumonia and underlying risk factors.<

SUBMITTER: von der Thusen J 

PROVIDER: S-EPMC7267318 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature