Alcohol Drinking and Bladder Cancer Risk From a Pooled Analysis of Ten Cohort Studies in Japan.

ABSTRACT:

Background

The association of alcohol drinking with bladder cancer risk remains unclear in East Asian populations. Aldehyde dehydrogenase 2 (ALDH2) enzyme oxidizes alcohol-metabolized carcinogenic acetaldehyde into acetate. It is well known that the inactive ALDH2 carriers, specific to East Asian populations, have an increased risk of several cancer types because of increased exposure to acetaldehyde after alcohol consumption. The aim of this study was to examine the association between alcohol drinking and bladder cancer risk using data from ten population-based prospective cohort studies in Japan, where approximately 40% of the population has inactive ALDH2 enzyme.

Methods

We analyzed 340,497 Japanese participants with average follow-up of 13.4 years. The association betwe

SUBMITTER: Masaoka H 

PROVIDER: S-EPMC7280052 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature