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Sofosbuvir as a potential alternative to treat the SARS-CoV-2 epidemic.

ABSTRACT: As of today, there is no antiviral for the treatment of the SARS-CoV-2 infection, and the development of a vaccine might take several months or even years. The structural superposition of the hepatitis C virus polymerase bound to sofosbuvir, a nucleoside analog antiviral approved for hepatitis C virus infections, with the SARS-CoV polymerase shows that the residues that bind to the drug are present in the latter. Moreover, a multiple alignment of several SARS-CoV-2, SARS and MERS-related coronaviruses polymerases shows that these residues are conserved in all these viruses, opening the possibility to use sofosbuvir against these highly infectious pathogens.

SUBMITTER: Jacome R

PROVIDER: S-EPMC7283245 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Sofosbuvir as a potential alternative to treat the SARS-CoV-2 epidemic.

Jácome Rodrigo R Campillo-Balderas José Alberto JA Ponce de León Samuel S Becerra Arturo A Lazcano Antonio A

Scientific reports 20200609 1

As of today, there is no antiviral for the treatment of the SARS-CoV-2 infection, and the development of a vaccine might take several months or even years. The structural superposition of the hepatitis C virus polymerase bound to sofosbuvir, a nucleoside analog antiviral approved for hepatitis C virus infections, with the SARS-CoV polymerase shows that the residues that bind to the drug are present in the latter. Moreover, a multiple alignment of several SARS-CoV-2, SARS and MERS-related coronav ...[more]

PMID: 32518317

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