Klotho and vitamin D in multiple sclerosis: an Italian study.

ABSTRACT:

Introduction

Low vitamin D levels have been recognised as an important risk factor for autoimmune diseases, including multiple sclerosis (MS). MS is a multifactorial disease, the pathogenesis of which contributes both to genetic and environmental factors. Polymorphisms in genes codifying molecules involved in vitamin D homeostasis have been associated with hypovitaminosis D. However, the influence of polymorphisms of Klotho, which codify a protein with a pivotal role in vitamin D metabolism, have never been investigated. The aim of this study was to evaluate the association among genetic variants of Klotho, namely rs1207568 and rs9536314, serum 25(OH)D₃ levels, and multiple sclerosis (both risk and disease progression).

Material and methods

107 patients with MS an

SUBMITTER: Scazzone C 

PROVIDER: S-EPMC7286339 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature