Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer.

ABSTRACT:

Background

Cancer subtype switching, which involves unclear cancer cell origin, cell fate decision, and transdifferentiation of cells within a confined tumor microenvironment, remains a major problem in pancreatic cancer (PDA).

Results

By analyzing PDA subtypes in The Cancer Genome Atlas, we identified that epigenetic silencing of apoptosis-associated tyrosine kinase (AATK) inversely was correlated with mRNA expression and was enriched in the quasi-mesenchymal cancer subtype. By comparing early mouse pancreatic lesions, the non-invasive regions showed AATK co-expression in cells with acinar-to-ductal metaplasia, nuclear VAV1 localization, and cell cycle suppression; but the invasive lesions conversely revealed diminished AATK expression in those with poorly differentiated hi

SUBMITTER: Ding LY 

PROVIDER: S-EPMC7301993 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature