Diauxie and co-utilization of carbon sources can coexist during bacterial growth in nutritionally complex environments.

ABSTRACT: It is commonly thought that when multiple carbon sources are available, bacteria metabolize them either sequentially (diauxic growth) or simultaneously (co-utilization). However, this view is mainly based on analyses in relatively simple laboratory settings. Here we show that a heterotrophic marine bacterium, Pseudoalteromonas haloplanktis, can use both strategies simultaneously when multiple possible nutrients are provided in the same growth experiment. The order of nutrient uptake is partially determined by the biomass yield that can be achieved when the same compounds are provided as single carbon sources. Using transcriptomics and time-resolved intracellular ¹H-¹³C NMR, we reveal specific pathways for utilization of various amino acids. Finally, theoretical modell

SUBMITTER: Perrin E 

PROVIDER: S-EPMC7305145 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature