Dataset Information

Global molecular diversity of RSV - the "INFORM RSV" study.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) is a global cause of severe respiratory morbidity and mortality in infants. While preventive and therapeutic interventions are being developed, including antivirals, vaccines and monoclonal antibodies, little is known about the global molecular epidemiology of RSV. INFORM is a prospective, multicenter, global clinical study performed by ReSViNET to investigate the worldwide molecular diversity of RSV isolates collected from children less than 5 years of age.

Methods

The INFORM study is performed in 17 countries spanning all inhabited continents and will provide insight into the molecular epidemiology of circulating RSV strains worldwide. Sequencing of > 4000 RSV-positive respiratory samples is planned to detect temporal and geographical molecular patterns on a molecular level over five consecutive years. Additionally, RSV will be cultured from a subset of samples to study the functional implications of specific mutations in the viral genome including viral fitness and susceptibility to different monoclonal antibodies.

Discussion

The sequencing and functional results will be used to investigate susceptibility and resistance to novel RSV preventive or therapeutic interventions. Finally, a repository of globally collected RSV strains and a database of RSV sequences will be created.

SUBMITTER: Langedijk AC

PROVIDER: S-EPMC7316634 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Publications

Global molecular diversity of RSV - the "INFORM RSV" study.

Langedijk Annefleur C AC Lebbink Robert Jan RJ Naaktgeboren Christiana C Evers Anouk A Viveen Marco C MC Greenough Anne A Heikkinen Terho T Stein Renato T RT Richmond Peter P Martinón-Torres Federico F Nunes Marta M Hosoya Mitsuaki M Keller Christian C Bauck Monika M Cohen Robert R Papenburg Jesse J Pernica Jeffrey J Hennus Marije P MP Jin Hong H Tabor David E DE Tovchigrechko Andrev A Ruzin Alexey A Abram Michael E ME Wilkins Deidre D Wildenbeest Joanne G JG Kragten-Tabatabaie Leyla L Coenjaerts Frank E J FEJ Esser Mark T MT Bont Louis J LJ

BMC infectious diseases 20200626 1

<h4>Background</h4>Respiratory syncytial virus (RSV) is a global cause of severe respiratory morbidity and mortality in infants. While preventive and therapeutic interventions are being developed, including antivirals, vaccines and monoclonal antibodies, little is known about the global molecular epidemiology of RSV. INFORM is a prospective, multicenter, global clinical study performed by ReSViNET to investigate the worldwide molecular diversity of RSV isolates collected from children less than ...[more]

PMID: 32591017

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Dataset Information

Global molecular diversity of RSV - the "INFORM RSV" study.

Background

Methods

Discussion

Publications

Global molecular diversity of RSV - the "INFORM RSV" study.

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