Comparison of hypertrophic scarring on a red Duroc pig and a Guangxi Mini Bama pig.

ABSTRACT: Lay SummaryPigs, with an anatomical and physiological skin architecture similar to that of the human, have been studied extensively as models for wound healing and scarring. However, the red Duroc pig, as a frequently used animal model for human wound/scar-related research, has the shortcoming of rapid growth in size and weight, which gives rise to difficulty in its handling and brings about enormous cost. The Mini Bama pig grows much slower and can be a potential replacement. This study compares wound healing and subsequent scarring between the Duroc and Mini Bama pigs with a time span of 35 weeks. Other than clinical appearance at week 35, when the Duroc scars showed an obvious hyperpigmentation while the Mini Bama scars showed slight hypopigmentation, the trends of change in shape, histological appearance (epidermis thickness) and collagen deposition in the tissues are similar in both types of pigs.

SUBMITTER: Ning X 

PROVIDER: S-EPMC7318807 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature