A network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic heart failure.

ABSTRACT:

Aims

Heart failure (HF) is frequently caused by an ischaemic event (e.g. myocardial infarction) but might also be caused by a primary disease of the myocardium (cardiomyopathy). In order to identify targeted therapies specific for either ischaemic or non-ischaemic HF, it is important to better understand differences in underlying molecular mechanisms.

Methods and results

We performed a biological physical protein-protein interaction network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic HF. First, differentially expressed plasma protein biomarkers were identified in 1160 patients enrolled in the BIOSTAT-CHF study, 715 of whom had ischaemic HF and 445 had non-ischaemic HF. Second, we constructed an enriched physical protein-protei

SUBMITTER: Sama IE 

PROVIDER: S-EPMC7319432 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature