High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot.

ABSTRACT:

Background

Prostate cancer (PCa) has a profoundly immunosuppressive microenvironment and is commonly immune excluded with few infiltrative lymphocytes and low levels of immune activation. High-dose radiation has been demonstrated to stimulate the immune system in various human solid tumors. We hypothesized that localized radiation therapy, in the form of high dose-rate brachytherapy (HDRBT), would overcome immune suppression in PCa.

Methods

To investigate whether HDRBT altered prostate immune context, we analyzed preradiation versus postradiation human tissue from a cohort of 24 patients with localized PCa that received HDRBT as primary treatment (RadBank cohort). We performed Nanostring immune gene expression profiling, digital spatial profiling, and high-throughput immune

SUBMITTER: Keam SP 

PROVIDER: S-EPMC7319782 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature