FASN Protein Overexpression Indicates Poor Biochemical Recurrence-Free Survival in Prostate Cancer.

ABSTRACT:

Backgrounds

Fatty acid synthase (FASN) has been regarded as a prognostic marker in prostate cancer (PCa). In this study, we evaluated FASN expression at both mRNA and protein levels and assessed the association between FASN expression and prognosis in male Han Chinese with PCa treated with radical prostatectomy (RP).

Methods

Expression profile and prognostic value of FASN were analyzed in tissue microarray (TMA) and data retrieved from databases including TCGA public database, GEO database, and our sequencing data with whole clinicopathological characteristics.

Results

FASN expression was associated with clinical parameters and biochemical recurrence of prostate cancer. The relative expression of FASN mRNA was higher in the tumor tissue in all public databases and our

SUBMITTER: Cao Z 

PROVIDER: S-EPMC7321525 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature