Dataset Information

Undefeated-Changing the phenamacril scaffold is not enough to beat resistant Fusarium.

ABSTRACT: Filamentous fungi belonging to the genus Fusarium are notorious plant-pathogens that infect, damage and contaminate a wide variety of important crops. Phenamacril is the first member of a novel class of single-site acting cyanoacrylate fungicides which has proven highly effective against important members of the genus Fusarium. However, the recent emergence of field-resistant strains exhibiting qualitative resistance poses a major obstacle for the continued use of phenamacril. In this study, we synthesized novel cyanoacrylate compounds based on the phenamacril-scaffold to test their growth-inhibitory potential against wild-type Fusarium and phenamacril-resistant strains. Our findings show that most chemical modifications to the phenamacril-scaffold are associated with almost complete loss of fungicidal activity and in vitro inhibition of myosin motor domain ATPase activity.

SUBMITTER: Wollenberg RD

PROVIDER: S-EPMC7323951 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Undefeated-Changing the phenamacril scaffold is not enough to beat resistant Fusarium.

Wollenberg Rasmus D RD Donau Søren S SS Taft Manuel H MH Balázs Zoltan Z Giese Sven S Thiel Claudia C Sørensen Jens L JL Nielsen Thorbjørn T TT Giese Henriette H Manstein Dietmar J DJ Wimmer Reinhard R Sondergaard Teis E TE

PloS one 20200629 6

Filamentous fungi belonging to the genus Fusarium are notorious plant-pathogens that infect, damage and contaminate a wide variety of important crops. Phenamacril is the first member of a novel class of single-site acting cyanoacrylate fungicides which has proven highly effective against important members of the genus Fusarium. However, the recent emergence of field-resistant strains exhibiting qualitative resistance poses a major obstacle for the continued use of phenamacril. In this study, we ...[more]

PMID: 32598376

Dataset Information

Undefeated-Changing the phenamacril scaffold is not enough to beat resistant Fusarium.

Publications

Undefeated-Changing the phenamacril scaffold is not enough to beat resistant Fusarium.

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