Reductive dearomative arylcarboxylation of indoles with CO₂ via visible-light photoredox catalysis.

ABSTRACT: Catalytic reductive coupling of two electrophiles and one unsaturated bond represents an economic and efficient way to construct complex skeletons, which is dominated by transition-metal catalysis via two electron transfer. Herein, we report a strategy of visible-light photoredox-catalyzed successive single electron transfer, realizing dearomative arylcarboxylation of indoles with CO₂. This strategy avoids common side reactions in transition-metal catalysis, including ipso-carboxylation of aryl halides and β-hydride elimination. This visible-light photoredox catalysis shows high chemoselectivity, low loading of photocatalyst, mild reaction conditions (room temperature, 1 atm) and good functional group tolerance, providing great potential for the synthesis of valuable but difficu

SUBMITTER: Zhou WJ 

PROVIDER: S-EPMC7324572 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature