Critical physicochemical attributes of chitosan nanoparticles admixed lactose-PEG 3000 microparticles in pulmonary inhalation.
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ABSTRACT:
SUBMITTER: Alhajj N
PROVIDER: S-EPMC7327774 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
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Critical physicochemical attributes of chitosan nanoparticles admixed lactose-PEG 3000 microparticles in pulmonary inhalation.
Alhajj Nasser N Zakaria Zabliza Z Naharudin Idanawati I Ahsan Fakhrul F Li Wenji W Wong Tin Wui TW
Asian journal of pharmaceutical sciences 20190319 3
Chitosan nanoparticles are exhalation prone and agglomerative to pulmonary inhalation. Blending nanoparticles with lactose microparticles (∼5 µm) could mutually reduce their agglomeration through surface adsorption phenomenon. The chitosan nanoparticles of varying size, size distribution, zeta potential, crystallinity, shape and surface roughness were prepared by spray drying technique as a function of chitosan, surfactant and processing conditions. Lactose-polyethylene glycol 3000 (PEG3000) mic ...[more]
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