Ontology highlight
ABSTRACT:
SUBMITTER: Clark DJ
PROVIDER: S-EPMC7331093 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Cell 20191001 4
To elucidate the deregulated functional modules that drive clear cell renal cell carcinoma (ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic, and phosphoproteomic characterization of treatment-naive ccRCC and paired normal adjacent tissue samples. Genomic analyses identified a distinct molecular subgroup associated with genomic instability. Integration of proteogenomic measurements uniquely identified protein dysregulation of cellular mechanisms impacted by genom ...[more]