Lung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT Ligand KITLG/SCF and Gene-By-Air-Pollution Interaction.

ABSTRACT: Baseline lung function, quantified as forced expiratory volume in the first second of exhalation (FEV₁), is a standard diagnostic criterion used by clinicians to identify and classify lung diseases. Using whole-genome sequencing data from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine project, we identified a novel genetic association with FEV₁ on chromosome 12 in 867 African American children with asthma (P = 1.26 × 10^-8, β = 0.302). Conditional analysis within 1 Mb of the tag signal (rs73429450) yielded one major and two other weaker independent signals within this peak. We explored statistical and functional evidence for all variants in linkage disequilibrium with the three independent signals and yielded nine var

SUBMITTER: Mak ACY 

PROVIDER: S-EPMC7337089 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature