Serum Metabolites in Hand-Arm Vibration Exposed Workers.

ABSTRACT:

Objective

To investigate whether low molecular organic biomarkers could be identified in blood samples from vibration exposed workers using a metabolomics.

Methods

The study population consisted of 38 metalworkers. All participants underwent a standardized medical examination. Blood samples were collected before and after work shift and analyzed with gas chromatography time-of-flight mass spectrometry. Multivariate modeling (orthogonal partial least-squares analysis with discriminant analysis [OPLS-DA]) were used to verify differences in metabolic profiles.

Results

Twenty-two study participants reported vascular symptoms judged as vibration-related. The metabolic profile from participants with vibration-induced white fingers (VWF) was distinctly separated from partici

SUBMITTER: Vihlborg P 

PROVIDER: S-EPMC7337105 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature