Effect of food on the pharmacokinetics of the WEE1 inhibitor adavosertib (AZD1775) in patients with advanced solid tumors.

ABSTRACT:

Purpose

To support future dosing recommendations, the effect of food on the pharmacokinetics of adavosertib, a first-in-class, small-molecule reversible inhibitor of WEE1 kinase, was assessed in patients with advanced solid tumors.

Methods

In this Phase I, open-label, randomized, two-period, two-sequence crossover study, the pharmacokinetics of a single 300 mg adavosertib dose were investigated in fed versus fasted states.

Results

Compared with the fasted state, a high-fat, high-calorie meal (fed state) decreased adavosertib maximum plasma concentration (C_max) by 16% and systemic exposure (area under the plasma concentration-time curve [AUC]) by 6%; AUC_0-t decreased by 7% and time to maximum plasma concentration was delayed by 1.97 h (P = 0.0009)

SUBMITTER: Nagard M 

PROVIDER: S-EPMC7338825 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature