Safety and efficacy of cell therapies in pediatric heart disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Adult clinical trials have reported safety and the therapeutic potential of stem cells for cardiac disease. These observations have now translated to the pediatric arena. We conducted a meta-analysis to assess safety and efficacy of cell-based therapies in animal and human studies of pediatric heart disease.

Methods and results

A literature search was conducted to examine the effects of cell-based therapies on: (i) safety and (ii) cardiac function. In total, 18 pre-clinical and 13 human studies were included. Pre-clinical: right ventricular dysfunction was the most common animal model (80%). Cardiac-derived (28%) and umbilical cord blood (24%) cells were delivered intravenously (36%) or intramyocardially (35%). Mortality was similar between cell-based and control

SUBMITTER: Martinez J 

PROVIDER: S-EPMC7341627 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature