Oral intermittent vitamin D substitution: influence of pharmaceutical form and dosage frequency on medication adherence: a randomized clinical trial.

ABSTRACT:

Background

To assess adherence to and preference for vitamin D substitution with different pharmaceutical forms and frequencies of administration.

Methods

A focus group of stakeholders aimed at preparing the design of an interventional, randomized, cross-over study with 2 × 2 groups obtaining monthly or weekly vitamin D products in liquid or solid form for 3 months each. Dosage corresponds to cumulated amount of recommended 800 IU daily (5.600 IU weekly / 24.000 IU monthly). Main inclusion criteria were a vitamin D serum value < 50 nmol/l and age ≥ 18 years. Primary endpoint was adherence, secondary endpoints were preferences and vitamin D serum levels.

Results

The focus group reached consensus for preference of a monthly administration of solid forms to adults. Full

SUBMITTER: Rothen JP 

PROVIDER: S-EPMC7353738 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature