Bioengineered carina reconstruction using In-Vivo Bioreactor technique in human: proof of concept study.

ABSTRACT:

Backgrounds

Long-segment airway defect reconstruction, especially when carina is invaded, remains a challenge in clinical setting. Previous attempts at bioengineered carina reconstruction failed within 90 days due to delayed revascularization and recurrent infection.

Methods

To establish the feasibility of carina bioengineering use In-Vivo Bioreactor technique. Uncontrolled single-center cohort study including three patients with long-segment airway lesions invading carina. Radical resection of the lesions was performed using standard surgical techniques. After resection, In-Vivo Bioreactor airway reconstruction was performed using a nitinol stent wrapped in two layers of acellularized dermis matrix (ADM). Two Port-a-Cath catheters connected to two portable peristaltic pumps

SUBMITTER: Xu Y 

PROVIDER: S-EPMC7354144 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature